Synonyms: 6-methylene androstere-1, 4-diene-3, 17-dione

Molecular formula: C20H24O2

Molecular weight: 296.40

Appearance: White to light yellow crystal powder

For exemestane, steroid aromatase inactivator is a pseudo-substrate of aromatase. Since estrogen in postmenopausal women is mainly produced by androgen (produced by adrenal cortex) in the peripheral tissue under the action of aromatase transformation, this product by irreversibly binding with aromatase active site to inactivate it, thus significantly reducing the blood circulation of estrogen in menopausal women.

Exemestane is a steroidal aromatase inactivator and a pseudosubstrate of aromatase. The estrogen of menopausal women is mainly produced by androgens (produced by the adrenal cortex) under the action of aromatase in the peripheral tissues. 

Exemestane inactivates aromatase by irreversibly binding to the active site of it, which is obvious reduce the level of estrogen in the blood circulation of menopausal women.